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Alprazolam for Treatment of panic disorders (attacks of panic and anxiety)

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Treatment of panic disorders (attacks of panic and anxiety)

Immediate release

  • 0.5 mg orally once every 8 hours; can be adjusted once every 3-4 days with 1 mg or less / day
  • Average dose of drug: 5-6 mg / day orally
  • May require up to 10 mg / day orally once every 8 hours

With extended release

  • Dose of drug 0.5-1 mg orally once a day; can be adjusted once every 3-4 days with 1 mg or less / day
  • Average drug dose: 3-6 mg orally once a day

Treatment of anxiety associated with depression

  • Immediate release: Reduce the initial dose to 0.25 mg once every 8-12 hours
  • Extended release: 0.5 mg orally once a day

Treatment of premenstrual syndrome

  • 0.25 mg orally once every 6-12 hours; start treatment on day 16-18 of the menses (no more than 3-4 mg / day); reduced dose for 2-3 days once menstruation occurs

Dosage adjustments

Renal impairment

Be careful; not studied
Advanced liver failure

Immediate release

  • Lower the initial dose to 0.25 mg once every 8-12 hours
  • Extended release: 0.5 mg orally once a day

Not recommended for use in patients 18 years of age and younger.

Treatment of geriatric dose of panic disorder

Immediate release:

  • Lower the initial dose of medication to 0.25 mg orally once every 8-12 hours; may increase gradually as needed and as tolerated; can increase by 1 mg or less / day every 3-4 days to an average dose of 5-6 mg / day

With extended release:

  • Start with 0.5 mg orally once a day; may increase gradually as needed and as tolerated; can increase by 1 mg or less / day every 3-4 days to 3-6 mg / day

Geriatric dose anxiety associated with depression

  • Lower the initial dose of medication to 0.25 mg orally once every 8-12 hours; may increase gradually as needed and as tolerated; can increase by 1 mg or less / day every 3-4 days to 1-4 mg / day
  • Maintenance: 1-4 mg / day orally once every 8 hours

Considerations for geriatric dosing

  • Use the smallest dose of this medication to prevent ataxia and over-sedation and other unwanted side effects or symptoms
  • The elderly are particularly sensitive to benzodiazepines; higher plasma levels due to reduced clearance
  • Average half-life: 16.3 hours in healthy elderly (range: 9-26.9 hours), compared to 11 hours in healthy adults (range: 6.3-15.8 hours)

WHAT ARE SIDE EFFECTS RELATED TO THE USE OF ALPRAZOLAM (XANAX)?

Common side effects of alprazolam (Xanax) include:

  • Sleepiness
  • Depression
  • Headache pain
  • Constipation
  • Diarrhea
  • Dry mouth
  • Reduced coordination
  • Increased or decreased appetite
  • Fatigue
  • Memory issues
  • Irritability
  • Decreased salivation
  • Cognitive disorders
  • Insomnia
  • Dizziness
  • Faint
  • Difficulty speaking
  • Nausea / vomiting
  • Weight gain
  • Stuffy nose
  • Decreased or increased libido
  • Menstrual disorder
  • Difficult to pee
  • Fast heartbeat
  • Confusion
  • Blurred vision
  • Low blood pressure (hypotension)
  • Agitation / restlessness
  • Dizziness
  • Increased salivation
  • Nervousness
  • Tremor
  • Talkative
  • Incontinence
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